| Identification | Back Directory | [Name]
(4-MORPHOLIN-4-YL-PHENYL)METHANOL | [CAS]
280556-71-0 | [Synonyms]
BUTTPARK 98\50-30
RARECHEM AL BD 1130
4-Morpholinobenzyl Alcohol
(4-MORPHOLINOPHENYL)METHANOL
4-(Morpholin-4-yl)benzyl alcohol
4-(4-Morpholinyl)benzenemethanol
(4-MORPHOLIN-4-YL-PHENYL)METHANOL
Benzenemethanol, 4-(4-morpholinyl)-
(4-MORPHOLIN-4-YL-PHENYL)METHANOL 95%
4-(Morpholin-4-yl)benzyl alcohol, 4-[4-(Hydroxymethyl)phenyl]morpholine | [Molecular Formula]
C11H15NO2 | [MDL Number]
MFCD01057413 | [MOL File]
280556-71-0.mol | [Molecular Weight]
193.24 |
| Chemical Properties | Back Directory | [Melting point ]
96 °C | [Boiling point ]
378.4±42.0 °C(Predicted) | [density ]
1.160±0.06 g/cm3(Predicted) | [storage temp. ]
Storage temp. 2-8°C | [form ]
powder | [pka]
14.40±0.10(Predicted) | [color ]
White |
| Hazard Information | Back Directory | [Synthesis]
C. Synthesis of 4-(4-morpholinyl)benzyl alcohol. At -10 °C, 4-(4-morpholinyl)benzoic acid (1.00 g, 4.83 mmol) and 4-methylmorpholine (0.53 mL, 4.8 mmol) were dissolved in tetrahydrofuran (25 mL), followed by the addition of ethyl chloroformate (0.46 mL, 4.8 mmol). After 0.25 h of reaction, sodium borohydride (550 mg, 14.5 mmol) was added to the mixture followed by slow addition of methanol (50 mL). Next, the mixture was treated with 5% aqueous acetic acid, after which the mixture was concentrated. The residue was purified by silica gel column chromatography (eluent: ethyl acetate/hexane) to give 164 mg (18% yield) of 4-morpholinobenzyl alcohol. The product was characterized by 1H NMR, IR spectroscopy, field desorption mass spectrometry (FD-MS, m/e 193 (M+)), and elemental analysis (calculated values for C11H15NO2: C, 68.37; H, 7.82; N, 7.25; measured values: C, 68.46; H, 7.95; N, 7.21). | [References]
[1] Patent: US6610704, 2003, B1 |
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