| Chemical Properties | Back Directory | [Boiling point ]
581.6±50.0 °C(predicted) | [density ]
1.438±0.06 g/cm3(Temp: 20 °C; Press: 760 Torr)(predicted) | [pka]
2.37±0.10(predicted) |
| Hazard Information | Back Directory | [Uses]
XOR/URAT1-IN-1 (Compound II15) is a dual inhibitor for xanthine oxidoreductase (XOR) and uric acid transporter 1 (URAT1), with IC50 of 6 nM and 12.9 μM. XOR/URAT1-IN-1 lowers the levels of uric acid in Potassium oxonate (HY-17511)/Hypoxanthine (HY-N0091)-induced acute hyperuricemia mouse model[1]. | [References]
[1] Yang C, et al., Design, synthesis, and biological evaluation of 3-phenyl substituted pyridine derivatives as potential dual inhibitors of XOR and URAT1. Eur J Med Chem. 2024 May 5;271:116407. DOI:10.1016/j.ejmech.2024.116407 |
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