| Hazard Information | Back Directory | [Uses]
AZ7976 (Compound 42) is a highly selective agonist for the Relaxin Family Peptide Receptor 1 (RXFP1) (pEC50 > 10.5). AZ7976 enhances RXFP1's cAMP signaling through an allosteric mechanism, thereby physiologically increasing heart rate. AZ7976 can be used in the field of cardiovascular disease research[1]. | [References]
[1] Granberg KL, et al. Identification of Novel Series of Potent and Selective Relaxin Family Peptide Receptor 1 (RXFP1) Agonists. J Med Chem. 2024 Mar 28;67(6):4442-4462. DOI:10.1021/acs.jmedchem.3c02183 |
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Biorbyt Ltd.
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