| Identification | Back Directory | [Name]
(2-THIENYLMETHYLENE)METHANE-1,1-DICARBONITRILE | [CAS]
28162-32-5 | [Synonyms]
THDCV
AKOS 92447
AKOS USSH-4110240
RARECHEM AL BX 0177
2-Thenylidenemalononitrile
(2-Thenylidene)malononitrile
2-(2-Thenylidene)malononitrile
2-thienylmethylenemalononitrile
(2-thienylmethylene)-malononitril
(thien-2-ylmethylene)malononitrile
2-(2-THIENYLMETHYLENE)MALONONITRILE
2-(2-THIENYLMETHYLIDENE)MALONONITRILE
2-(2-Thienylmethylene)propanedinitrile
2-(Thiophen-2-ylmethylene)malononitrile
Propanedinitrile, 2-(2-thienylmethylene)-
(2-THIENYLMETHYLENE)METHANE-1,1-DICARBONITRILE | [Molecular Formula]
C8H4N2S | [MDL Number]
MFCD00114006 | [MOL File]
28162-32-5.mol | [Molecular Weight]
160.2 |
| Chemical Properties | Back Directory | [Melting point ]
91 °C | [Boiling point ]
308.6±27.0 °C(Predicted) | [density ]
1.302±0.06 g/cm3(Predicted) | [storage temp. ]
2-8°C(protect from light) |
| Hazard Information | Back Directory | [Synthesis Reference(s)]
The Journal of Organic Chemistry, 14, p. 790, 1949 DOI: 10.1021/jo01157a011 | [Synthesis]
The general procedure for the synthesis of (2-thienylmethylene)methane-1,1-dicarbonitrile from 2-thiophenecarboxaldehyde and malononitrile was as follows: 5.068 g (50 mmol) of 2-thiophenecarboxaldehyde (I-10) and 0.5 g (5 mol%) of Ru/C catalyst were added to a reaction flask. Subsequently, 3.303 g (50 mmol) of malononitrile (II) and 100 mL of ethanol were added and the reaction was stirred for 15 hours at room temperature. The subsequent processing steps were the same as in Example 1. Finally, 7.769 g of the target product was obtained with 97.0% yield and 98.0% purity analyzed by GC-MS. | [References]
[1] RSC Advances, 2013, vol. 3, # 45, p. 23075 - 23079
[2] Tetrahedron Letters, 1982, vol. 23, # 47, p. 4927 - 4928
[3] Green Chemistry, 2010, vol. 12, # 3, p. 514 - 517
[4] Patent: CN108383755, 2018, A. Location in patent: Paragraph 0076-0079
[5] European Journal of Organic Chemistry, 2004, # 3, p. 546 - 551 |
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