| Identification | Back Directory | [Name]
Benzenesulfonamide, N-(6,12-dihydro-6,12-dioxoindolo[2,1-b]quinazolin-2-yl)-4-methoxy- | [CAS]
2816993-09-4 | [Synonyms]
Anti-inflammatory agent 33
Benzenesulfonamide, N-(6,12-dihydro-6,12-dioxoindolo[2,1-b]quinazolin-2-yl)-4-methoxy- | [Molecular Formula]
C22H15N3O5S | [MOL File]
2816993-09-4.mol | [Molecular Weight]
433.44 |
| Hazard Information | Back Directory | [Uses]
Anti-inflammatory agent 33 is a potent p38α inhibitor. Anti-inflammatory agent 33 inhibits NO production. Anti-inflammatory agent 33 inhibits LPS-induced iNOS, COX-2, p-p38α, p-MK2 protein expression. Anti-inflammatory agent 33 shows anti-inflammatory activity[1]. | [in vivo]
Anti-inflammatory agent 33 (10, 30 mg/kg; once a day for 14 days) shows anti-inflammatory activity in a dose-dependent manner in rats[1]. | Animal Model: | 160-180 g, female Sprague–Dawley rats (AIA model)[1] | | Dosage: | 10, 30 mg/kg | | Administration: | Once a day for 14 days | | Result: | Significantly reduced the swelling of the feet of the rats in a dose-dependent manner. |
| [References]
[1] Du J, et al. Novel tryptanthrin derivatives with benzenesulfonamide substituents: Design, synthesis, and anti-inflammatory evaluation. Eur J Med Chem. 2022 Nov 25;246:114956. DOI:10.1016/j.ejmech.2022.114956 |
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