| Identification | Back Directory | [Name]
4(1H)-Quinazolinone, 5-chloro-2,3-dihydro-2-(3-methylphenyl)- | [CAS]
2819989-61-0 | [Synonyms]
PBRM1BD2IN5
PBRM1-BD2-IN-5
4(1H)-Quinazolinone, 5-chloro-2,3-dihydro-2-(3-methylphenyl)- | [Molecular Formula]
C15H13ClN2O | [MOL File]
2819989-61-0.mol | [Molecular Weight]
272.73 |
| Chemical Properties | Back Directory | [Boiling point ]
542.3±50.0 °C(Predicted) | [density ]
1?+-.0.06 g/cm3(Predicted) | [form ]
Solid | [pka]
12.55±0.40(Predicted) | [color ]
White to off-white |
| Hazard Information | Back Directory | [Uses]
PBRM1-BD2-IN-5 is a potent PBRM1 Bromodomain inhibitor with Kd values of 1.5 μM and 3.9 μM for PBRM1-BD2 and PBRM1-BD5, respectively, and an IC50 value of 0.26 μM for PBRM1-BD2. PBRM1-BD2-IN-5 reduces the binding of full-length PBRM1 within the PBAF complex in cell lysates to acetylated histone peptide. PBRM1-BD2-IN-5 can be used to research anticancer[1]. | [References]
[1] Shishodia S, et al. Selective and Cell-Active PBRM1 Bromodomain Inhibitors Discovered through NMR Fragment Screening. J Med Chem. 2022 Oct 13. DOI:10.1021/acs.jmedchem.2c00864 |
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