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Parp7-in-18 (Compund 8) is a selective PARP7 inhibitor with an IC50 of 0.11 nM. PARP7-IN-18 exhibits good anticancer activity and pharmacokinetic properties[1]. | [References]
[1] Xu J, et al. Discovery of tricyclic PARP7 inhibitors with high potency, selectivity, and oral bioavailability[J]. European Journal of Medicinal Chemistry, 2024: 116160. |
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