2820064-05-7

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2820064-05-7 Structure

Identification	Back Directory
[Name] LRAT-IN-1
[CAS] 2820064-05-7
[Synonyms] LRAT-IN-1 Benzenecarboximidamide, 3-[2-[(dodecylsulfonyl)amino]-3-[4-(methylsulfonyl)-1-piperazinyl]-3-oxopropyl]-
[Molecular Formula] C27H47N5O5S2
[MOL File] 2820064-05-7.mol
[Molecular Weight] 585.83

Chemical Properties	Back Directory
[Boiling point ] 760.7±70.0 °C(predicted)
[density ] 1.25±0.1 g/cm3(Temp: 20 °C; Press: 760 Torr)(predicted)
[pka] 9.42±0.40(predicted)

Hazard Information	Back Directory
[Uses] LRAT-IN-1 (compound 1) is a retinol acyltransferase (LRAT) inhibitor (IC50=21.1 μM). LRAT-IN-1 provides anti-aging effects by inhibiting the esterification of retinol to form retinol esters, increasing the available retinol in the skin. Research on LRAT-IN-1 as an anti-aging ingredient in cosmetics[1].
[References] [1] Imfeld, et al. "Boosting of retinol activity using novel lecithin: Retinol acyltransferase inhibitors." International Journal of Cosmetic Science 46.4 (2024): 544-552. DOI:10.1111/ics.12968

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