| Identification | Back Directory | [Name]
Benzamide, 2-fluoro-N-[(1R)-1-methyl-2-[methyl(phenylmethyl)amino]ethyl]-4-[5-(trifluoromethyl)-1,2,4-oxadiazol-3-yl]- | [CAS]
2820208-97-5 | [Synonyms]
Benzamide, 2-fluoro-N-[(1R)-1-methyl-2-[methyl(phenylmethyl)amino]ethyl]-4-[5-(trifluoromethyl)-1,2,4-oxadiazol-3-yl]- | [Molecular Formula]
C21H20F4N4O2 | [MOL File]
2820208-97-5.mol | [Molecular Weight]
436.4 |
| Hazard Information | Back Directory | [Uses]
NT376 is a high potency and selectivity inhibitor of class-IIa Histone deacetylases (HDAC) with an IC50 value of 32 nM, similar to NT160 (HY-149285) (IC50= 46 nM) in HT-29 cells. NT376 is proming for research of various cancers and in the diseases of the central nervous system (CNS) such as Alzheimer’s and Huntington’s diseases[1]. | [IC 50]
HDAC4: 1.26 nM (IC50, HT-29 cells); HDAC5: 2.85 nM (IC50, HT-29 cells); HDAC1: 1483 nM (IC50, HT-29 cells); HDAC11: 4851 nM (IC50, HT-29 cells); Class I/IIb: >4000 nM (IC50, HT-29 cells); HDAC6: 5035 nM (IC50, HT-29 cells) | [References]
[1] Xu S, et al. Design and radiosynthesis of class-IIa HDAC inhibitor with high molar activity via repositioning the 18F-radiolabel[J]. Sci Rep. 2024 Jul 2;14(1):15100. DOI:10.1038/s41598-024-65668-z |
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