| Identification | Back Directory | [Name]
Hydroxy-PEG2-methylamine | [CAS]
282551-10-4 | [Synonyms]
MeNH-PEG3-OH
PEG3-methylamine
Hydroxy-PEG2-methylamine
Methylamino-PEG3-alcohol
2-(2-(2-(Methylamino)ethoxy) ethoxy)ethanol
Ethanol, 2-[2-[2-(methylamino)ethoxy]ethoxy]- | [Molecular Formula]
C7H17NO3 | [MDL Number]
MFCD30182052 | [MOL File]
282551-10-4.mol | [Molecular Weight]
163.21 |
| Chemical Properties | Back Directory | [Boiling point ]
250.0±20.0 °C(Predicted) | [density ]
1.000±0.06 g/cm3(Predicted) | [form ]
Liquid | [pka]
14.36±0.10(Predicted) | [color ]
Yellow to brown |
| Hazard Information | Back Directory | [Description]
Hydroxy-PEG2-methylamine is a PEG linker containing a hydroxyl group with a methylamine group. The hydrophilic PEG spacer increases solubility in aqueous media. The hydroxyl group enables further derivatization or replacement with other reactive functional groups. The methylamine group is reactive with carboxylic acids, carbonyls (ketone, aldehyde) etc. | [Uses]
PEG3-methylamine is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs[1]. | [IC 50]
PEGs | [References]
[1] An S, et al. Small-molecule PROTACs: An emerging and promising approach for the development of targeted therapy drugs. EBioMedicine. 2018 Oct;36:553-562 DOI:10.1016/j.ebiom.2018.09.005 |
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