| Identification | Back Directory | [Name]
5,8-Quinolinedione, 6-chloro-7-[[1-[1-[4-(hydroxymethyl)phenyl]-1H-1,2,3-triazol-4-yl]ethyl]amino]- | [CAS]
2832887-40-6 | [Synonyms]
M5N36
5,8-Quinolinedione, 6-chloro-7-[[1-[1-[4-(hydroxymethyl)phenyl]-1H-1,2,3-triazol-4-yl]ethyl]amino]- | [Molecular Formula]
C20H16ClN5O3 | [MOL File]
2832887-40-6.mol | [Molecular Weight]
409.83 |
| Chemical Properties | Back Directory | [Boiling point ]
641.4±65.0 °C(Predicted) | [density ]
1.51±0.1 g/cm3(Predicted) | [form ]
Solid | [pka]
13.87±0.10(Predicted) | [color ]
Orange to red |
| Hazard Information | Back Directory | [Uses]
M5N36 is a potent and selective Cdc25C inhibitor with IC50 values of 0.15, 0.19, 0.06 μM for Cdc25A, Cdc25B, Cdc25C, respectively. M5N36 shows anti-proliferative activity and increases the expression of p-CDK1 and p-CDK2[1]. | [References]
[1] Tao Y, et al. Discovery of potent and selective Cdc25 phosphatase inhibitors via rapid assembly and in situ screening of Quinonoid-focused libraries. Bioorg Chem. 2021 Oct;115:105254. DOI:10.1016/j.bioorg.2021.105254 |
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