| Identification | Back Directory | [Name]
MAHANINE | [CAS]
28360-49-8 | [Synonyms]
MAHANINE
(-)-Mahanin
(3R)-3,11-Dihydro-3,5-dimethyl-3-(4-methyl-3-penten-1-yl)pyrano[3,2-a]carbazol-9-ol | [Molecular Formula]
C23H25NO2 | [MDL Number]
MFCD28137735 | [MOL File]
28360-49-8.mol | [Molecular Weight]
347.45 |
| Chemical Properties | Back Directory | [Melting point ]
100-loC | [Boiling point ]
548.0±50.0 °C(Predicted) | [density ]
1.168±0.06 g/cm3(Predicted) | [form ]
Solid | [pka]
10.11±0.40(Predicted) | [color ]
Light yellow to brown |
| Hazard Information | Back Directory | [Description]
This terpene alkaloid, also occurring in the leaves of Murraya koenigii Spreng., is
laevorotatory, having [α]D - 24.4°. Two methyl groups, one phenolic hydroxyl,
an imino group and an unsaturated side chain are present. | [Uses]
Mahanine is a carbazole alkaloid with various biological properties. Mahanine is a potent anticancer agent against different types of cancer cells. Mahanine exhibits antileishmanial activity and can be used for Leishmania infection research research. | [in vivo]
Mahanine (oral gavage; 20 mg/kg/40 mg/kg; b.w/day; 5 days) results in 89.1±4.1% reductions in parasite burden at 20 mg/kg, and leads to 96.2±0.3% reductions in parasite burden at 40 mg/kg in a well-established acute model to control Leishmaniainfection[1]. | Animal Model: | Balb/c mice with virulent AG83 promastigotes[1] | | Dosage: | 20?mg/kg-40 mg/kg | | Administration: | oral gavage; 20?mg/kg/40 mg/kg; b.w/day; 5 days | | Result: | Had the potential to clear parasite burden?in vivo.Exhibited almost complete reduction of parasite burden, upregulation of NO/iNOS/ROS/IL-12 and T?cell proliferation in vivo. |
| [IC 50]
Leishmania | [References]
Narasimhan, Paradkar, Kelkar.,lnd. J. Chem., 8,473 (1970) |
|
| Company Name: |
Inventichem
|
| Tel: |
+918790275459 |
| Website: |
www.inventichem.co |
|