| Chemical Properties | Back Directory | [Boiling point ]
861.4±65.0 °C(predicted) | [density ]
1.240±0.06 g/cm3(Temp: 20 °C; Press: 760 Torr)(predicted) | [form ]
Solid | [pka]
13.97±0.40(predicted) | [color ]
White to off-white |
| Hazard Information | Back Directory | [Uses]
(S,R,S)-AHPC-Me-C10-Br is a synthesized E3 ligase ligand-linker conjugate. (S,R,S)-AHPC-Me-C10-Br incorporates a VHL E3 ligase linker and MS432 based on the MEK1/2 inhibitor PD0325901[1]. | [IC 50]
VHL | [References]
[1] Wei J, et al. Discovery of a First-in-Class Mitogen-Activated Protein Kinase Kinase 1/2 Degrader.J Med Chem. 2019 Dec 12;62(23):10897-10911. DOI:10.1021/acs.jmedchem.9b01528 |
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