| Chemical Properties | Back Directory | [density ]
1.424±0.10 g/cm3(Temp: 25 °C; Press: 760 Torr)(predicted) | [form ]
Solid | [pka]
13.022±0.46(predicted) | [color ]
White to off-white | [InChIKey]
FNRHWODWSBDOOY-CYBMUJFWSA-N | [SMILES]
N(C1CC1)([C@@H]1CCCN(C1)C(=O)N)C(=O)NCC1C=CC(=CC=1F)OC(F)(F)F |
| Hazard Information | Back Directory | [Uses]
JNT-517 is an orally active, selective SLC6A19 allosteric inhibitor with an IC50 of 47 nM for human SLC6A19. JNT-517 can be used for the study of phenylketonuria (PKU)[1]. | [in vivo]
JN-170 (precursor of JN-517) (50-250 mg/kg, po, single dose) increases the excretion of amino acids in urine in mouse models[2]. | Animal Model: | C57Bl/6J wild-type mouse[2] | | Dosage: | 50-200 mg/kg | | Administration: | po, single dose | | Result: | Increaesed the excretion of glutamine, histidine, and threonine i urine. |
| [References]
[1] Dean G Brown, et al. Small molecule inhibitors of mammalian slc6a19 function. Patent WO2022192370A1.
[2] Wobst HJ, et al., SLC6A19 inhibition facilitates urinary neutral amino acid excretion and lowers plasma phenylalanine. JCI Insight. 2024 Nov 8;9(21):e182876. DOI:10.1172/jci.insight.182876 |
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| Company Name: |
yimo organism
|
| Tel: |
15915870272; 15915870272 |
| Website: |
https://www.yimobio.com |
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