| Identification | Back Directory | [Name]
5H-Thiazolo[3,2-a]pyrimidin-5-one, 7-(2,8-dimethylimidazo[1,2-b]pyridazin-6-yl)-2-(1-piperazinyl)- | [CAS]
2839311-21-4 | [Synonyms]
5H-Thiazolo[3,2-a]pyrimidin-5-one, 7-(2,8-dimethylimidazo[1,2-b]pyridazin-6-yl)-2-(1-piperazinyl)- | [Molecular Formula]
C18H19N7OS | [MOL File]
2839311-21-4.mol | [Molecular Weight]
381.45 |
| Hazard Information | Back Directory | [Uses]
mHTT-IN-1 (Example 1) is a potent mutant huntingtin (mHTT) inhibitor. mHTT is toxic and a major cause of the inherited autosomal dominant neurodegenerative disorder, Huntington's disease (HD). mHTT-IN-1 conducts the reduction of mHTT with an EC50 value of 46 nM[1]. | [References]
[1] Brom, et al. Preparation of thiazolopyrimidinone derivatives and uses thereof. World Intellectual Property Organization, WO2022194801 A1. 2022-09-22. |
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