| Identification | Back Directory | [Name]
Pyrimidine, 2-[2-methyl-5-(1-methylethyl)phenoxy]-4-[1-(4-piperidinyl)-4-[4-(trifluoromethyl)phenyl]-1H-imidazol-5-yl]- | [CAS]
2839318-17-9 | [Synonyms]
iBRD4-BD1
Pyrimidine, 2-[2-methyl-5-(1-methylethyl)phenoxy]-4-[1-(4-piperidinyl)-4-[4-(trifluoromethyl)phenyl]-1H-imidazol-5-yl]- | [Molecular Formula]
C29H30F3N5O | [MOL File]
2839318-17-9.mol | [Molecular Weight]
521.58 |
| Chemical Properties | Back Directory | [Boiling point ]
655.0±65.0 °C(Predicted) | [density ]
1.29±0.1 g/cm3(Predicted) | [form ]
Solid | [pka]
9.90±0.10(Predicted) | [color ]
White to off-white |
| Hazard Information | Back Directory | [Uses]
iBRD4-BD1 is selective BRD4 bromodomain inhibitor. iBRD4-BD1 has inhibition activity for BRD4 bromodomain with an IC50 value of 12 nM. iBRD4-BD1 can be used for the research of inflammation and oncology[1]. | [References]
[1] Anand Divakaran, et al. Development of an N-Terminal BRD4 Bromodomain-Targeted Degrader. ACS Med Chem Lett. 2022 Sep 29;13(10):1621-1627. DOI:10.1021/acsmedchemlett.2c00300 |
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