2839552-68-8

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2839552-68-8 Structure

Identification	Back Directory
[Name] 2,4(1H,3H)-Pyrimidinedione, 1-[5-[[(2S,4R)-1-[(4,4-difluorocyclohexyl)methyl]-2-methyl-4-piperidinyl]methyl]pyrazolo[1,5-a]pyridin-3-yl]dihydro-
[CAS] 2839552-68-8
[Synonyms] 2,4(1H,3H)-Pyrimidinedione, 1-[5-[[(2S,4R)-1-[(4,4-difluorocyclohexyl)methyl]-2-methyl-4-piperidinyl]methyl]pyrazolo[1,5-a]pyridin-3-yl]dihydro-
[Molecular Formula] C25H33F2N5O2
[MOL File] 2839552-68-8.mol
[Molecular Weight] 473.56

Chemical Properties	Back Directory
[density ] 1.39±0.1 g/cm3(Temp: 20 °C; Press: 760 Torr)(predicted)
[pka] 12.37±0.20(predicted)

Hazard Information	Back Directory
[Uses] WIZ degrader 1 (Compound 141) is a degrader for widely interspaced zinc finger motifs (WIZ) with an AC50 of 2 nM. WIZ degrader 1 induces the expression of fetal hemoglobin (HbF) with an EC50 of 6 mM. WIZ degrader 1 is used in research of inherited blood disorders[1].
[References] [1] BONAZZI S, et al., Pyrazolopyridine Derivatives and Uses thereof. US20240158374A1.

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