| Identification | Back Directory | [Name]
ABCA1 inducer 1 | [CAS]
2839627-76-6 | [Synonyms]
ABCA1 inducer 1
Benzoic acid, 3-chloro-5-[[[5-chloro-3-[[(4-ethoxy-3-methoxyphenyl)methylamino]sulfonyl]-2-thienyl]carbonyl]amino]-, ethyl ester | [Molecular Formula]
C24H24Cl2N2O7S2 | [MOL File]
2839627-76-6.mol | [Molecular Weight]
587.5 |
| Hazard Information | Back Directory | [Uses]
ABCA1 inducer 1 is a nonlipogenic ABCA1 inducer. ABCA1 inducer 1 increases ABCA1 expression, enhances apolipoprotein (APOE) lipidation and reverses multiple Alzheimer’s disease (AD) phenotypes, without increasing triglycerides in E3/4FAD mice that express human APOE 3/4[1]. | [References]
[1] Velma GR, et al. Nonlipogenic ABCA1 Inducers (NLAI) for Alzheimer's Disease Validated in a Mouse Model Expressing Human APOE3/APOE4. J Med Chem. 2024 Sep 12;67(17):15061-15079. DOI:10.1021/acs.jmedchem.4c00733 |
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