| Identification | Back Directory | [Name]
Benzamide, N-[6-(2,6-dichloro-3,5-dimethoxyphenyl)-1H-pyrazolo[3,4-b]pyridin-3-yl]-4-(3,3-dimethyl-1-piperazinyl)-, hydrochloride (1:1) | [CAS]
2847066-15-1 | [Synonyms]
Benzamide, N-[6-(2,6-dichloro-3,5-dimethoxyphenyl)-1H-pyrazolo[3,4-b]pyridin-3-yl]-4-(3,3-dimethyl-1-piperazinyl)-, hydrochloride (1:1) | [Molecular Formula]
C27H29Cl3N6O3 | [MOL File]
2847066-15-1.mol | [Molecular Weight]
591.92 |
| Hazard Information | Back Directory | [Uses]
Segigratinib hydrochloride (3D185) is a potent inhibitor of FGFR1/2/3 and CSF-1R; The IC50 values for FGFR1, FGFR2, FGFR3 and CSF-1R are 0.5, 1.3, 3.6 and 3.8 nM, respectively. Segigratinib hydrochloride has antitumor activity[1]. | [IC 50]
FGFR1: 0.5 nM (IC50); FGFR2: 1.3 nM (IC50); FGFR3: 3.6 nM (IC50) | [References]
[1] Peng X, et al. Preclinical evaluation of 3D185, a novel potent inhibitor of FGFR1/2/3 and CSF-1R, in FGFR-dependent and macrophage-dominant cancer models. J Exp Clin Cancer Res. 2019 Aug 22;38(1):372. DOI:10.1186/s13046-019-1357-y |
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