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Nampt activator-4 is a positive allosteric modulator (N-PAM) of nicotinamide phosphoribosyltransferase (NAMPT) with an EC50 of 0.058 μM. Nampt activator-4 can enhance the nicotinamide adenine dinucleotide (NAD+) in cells[1]. | [References]
[1] Shen,
Zhengnan et al. Synthesis, Optimization, and Structure-Activity Relationships
of Nicotinamide Phosphoribosyltransferase (NAMPT) Positive Allosteric
Modulators (N-PAMs). Journal of medicinal chemistry vol. 66,24 (2023):
16704-16727. DOI:10.1021/acs.jmedchem.3c01406 |
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