| Hazard Information | Back Directory | [Uses]
MMP-7-IN-2 (compound 16) is a selective inhibitor of MMP7 with an IC50 value of 16 nM[1]. | [IC 50]
MMP-7: 16 nM (IC50); MMP-14: 11000 nM (IC50); MMP-12: 12000 nM (IC50); MMP-2: 33000 (IC50); MMP-3: >100000 (IC50); MMP-8: >100000 (IC50); MMP-9: >100000 (IC50); MMP-13: >100000 (IC50) | [References]
[1] Hideaki Tabuse, et al. Discovery of Highly Potent and Selective Matrix Metalloproteinase-7 Inhibitors by Hybridizing the S1' Subsite Binder with Short Peptides. J Med Chem. 2022 Oct 13;65(19):13253-13263. DOI:10.1021/acs.jmedchem.2c01088 |
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