CK-963 (0.5 mg/kg, i.v.) reveals a pharmacokinetic profil with a clearance <25% in hepatic blood flow and a half-time of 0.6 h in Sprague-Dawley rats[1].
Pharmacokinetic Analysis in SD rats Model[1]
| Route | Dose (mg/kg) | Solubility (μM) | CL (mL·min/kg) | T1/2 (h) | Vd (L/kg) | PPB (% unbound) |
| i.v. | 0.5 | 107.2 | 7.1 | 0.6 | 3.8 | 3.7 |