| Chemical Properties | Back Directory | [Boiling point ]
560.169±60.00 °C(Press: 760.00 Torr)(predicted) | [density ]
1.368±0.14 g/cm3(Temp: 25 °C; Press: 760 Torr)(predicted) | [solubility ]
Acetonitrile: Soluble
DMSO: Soluble | [form ]
Solid | [pka]
4.227±0.10(predicted) | [color ]
Light yellow to yellow |
| Hazard Information | Back Directory | [Uses]
MC4033 shows IC50s of 39.4 μM, 52.1 μM, 41 μM and 30.1 μM in HCT116, H1299, A549 and U937, respectively[1].
MC4033 (25, 50, 100, and 200 μM, 72 h) reduces the level of H4K16Ac in HT29 cells, suggesting its ability to inhibit KAT8 in cells[1]. | [References]
[1] Fiorentino F, et al. First-in-Class Selective Inhibitors of the Lysine Acetyltransferase KAT8. J Med Chem. 2023 May 25;66(10):6591-6616 DOI:10.1021/acs.jmedchem.2c01937 |
|
|