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EGFR-IN-73 (Compound 3f) is a potent inhibitor for the most common EGFR mutation EGFR Del19 with an IC50 of 119 nM[1]. | [IC 50]
EGFRdel19: 119 nM (IC50); EGFRL858R: 820 nM (IC50); EGFRWT: >10 μM (IC50); EGFRL858R/T790M: >10 μM (IC50) | [References]
[1] Amrhein JA, et al. Macrocyclization of Quinazoline-Based EGFR Inhibitors Leads to Exclusive Mutant Selectivity for EGFR L858R and Del19. J Med Chem. 2022 Nov 16. DOI:10.1021/acs.jmedchem.2c01041 |
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