| Identification | Back Directory | [Name]
1H-Indazole, 3-(1H-benzimidazol-2-yl)-5-[3-(phenylmethoxy)phenyl]- | [CAS]
2863686-82-0 | [Synonyms]
1H-Indazole, 3-(1H-benzimidazol-2-yl)-5-[3-(phenylmethoxy)phenyl]- | [Molecular Formula]
C27H20N4O | [MOL File]
2863686-82-0.mol | [Molecular Weight]
416.47 |
| Chemical Properties | Back Directory | [Boiling point ]
715.4±70.0 °C(Predicted) | [density ]
1.317±0.06 g/cm3(Predicted) | [form ]
Solid | [pka]
10.75±0.10(Predicted) | [color ]
White to off-white |
| Hazard Information | Back Directory | [Uses]
SPEN-IN-1 (compound X1) is an inhibitor of SPEN which is a protein factor with a Kd value of 47 nM. SPEN-IN-1 has high selectivity for RepA, a 431-nucleotide domain in Xist (a non-coding RNA prototype) that comprises 8.5 units of a GC-rich motif responsible for gene silencing[1]. | [in vivo]
SPEN-IN-1 reduces RepA-SPEN interaction in vivo[1]. | [References]
[1] Aguilar R, et al. Targeting Xist with compounds that disrupt RNA structure and X inactivation. Nature. 2022 Apr;604(7904):160-166. DOI:10.1038/s41586-022-04537-z |
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