| Identification | Back Directory | [Name]
(+/-)-9-HYDROXY-5Z,7E,11Z,14Z,17Z-EICOSAPENTAENOIC ACID | [CAS]
286390-03-2 | [Synonyms]
(+/-)9-HEPE
OXOPDAZWPWFJEW-IMCWFPBLSA-N
(+/-)-9-HYDROXY-5Z,7E,11Z,14Z,17Z-EICOSAPENTAENOIC ACID
(+/-)-9-HYDROXY-5Z,7E,11Z,14Z,17Z-EICOSAPENTAENOIC ACID
5,7,11,14,17-Eicosapentaenoic acid, 9-hydroxy-, (5Z,7E,11Z,14Z,17Z)- | [Molecular Formula]
C20H30O3 | [MDL Number]
MFCD00216115 | [MOL File]
286390-03-2.mol | [Molecular Weight]
318.45 |
| Chemical Properties | Back Directory | [Boiling point ]
488.0±33.0 °C(Predicted) | [density ]
0.997±0.06 g/cm3(Predicted) | [storage temp. ]
Store at -20°C | [solubility ]
0.1 M Na2CO3: 2 mg/ml; DMF: Miscible; DMSO: Miscible; Ethanol: Miscible; PBS pH 7.2: 0.8 mg/ml | [pka]
4.73±0.10(Predicted) |
| Hazard Information | Back Directory | [Description]
(±)9-HEPE is produced by non-enzymatic oxidation of EPA. It contains equal amounts of 9(S)-HEPE and 9(R)-HEPE. The biological activity of (±)9-HEPE has not been clearly documented. | [Uses]
9-HEPE, a oxidation product of Eicosapentaenoic acid, is a racemic mixture of 9(R)-HEPE and 9(S)-HEPE. 9-HEPE induces fatty acid oxidation, adipogenesis, and glucose uptake via activation of PPARs in vivo[1]. | [Definition]
ChEBI: 9-HEPE is a HEPE that is (5Z,7E,11Z,14Z,17Z)-icosapentaenoic acid carrying a hydroxy substituent at position 9. It has a role as a marine metabolite. It is a conjugate acid of a 9-HEPE(1-). | [References]
[1] Hidetoshi Yamada, et al. Hydroxyeicosapentaenoic acids from the Pacific krill show high ligand activities for PPARs. J Lipid Res. 2014 May;55(5):895-904. DOI:10.1194/jlr.M047514 |
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