| Identification | Back Directory | [Name]
[1,2,4]Triazolo[1,5-a]pyrimidine-4(7H)-acetamide, N-[2-chloro-4-(trifluoromethyl)phenyl]-2-(3,6-dihydro-2H-pyran-4-yl)-5-ethyl-6-[4-[(5-hydroxy-6-methyl-4-pyrimidinyl)carbonyl]-1-piperazinyl]-7-oxo- | [CAS]
2869954-34-5 | [Synonyms]
Werner syndrome RecQ helicase-IN-1
N-(2-chloro-4-(trifluoromethyl)phenyl)-2-(2-(3,6-dihydro-2H-pyran-4-yl)-5-ethyl-6-(4-(5-hydroxy-6-methylpyrimidine-4-carbonyl)piperazin-1-yl)-7-oxo-[1,2,4]triazolo[1,5-a]pyrimidin-4(7H)-yl)acetamide
[1,2,4]Triazolo[1,5-a]pyrimidine-4(7H)-acetamide, N-[2-chloro-4-(trifluoromethyl)phenyl]-2-(3,6-dihydro-2H-pyran-4-yl)-5-ethyl-6-[4-[(5-hydroxy-6-methyl-4-pyrimidinyl)carbonyl]-1-piperazinyl]-7-oxo- | [Molecular Formula]
C31H31ClF3N9O5 | [MOL File]
2869954-34-5.mol | [Molecular Weight]
702.08 |
| Chemical Properties | Back Directory | [density ]
1.58±0.1 g/cm3(Predicted) | [solubility ]
DMSO: Slightly soluble: 0.1-1 mg/ml | [form ]
Solid | [pka]
5.87±0.45(Predicted) | [color ]
White to light yellow | [InChIKey]
XKYVECRUZPCRQR-UHFFFAOYSA-N | [SMILES]
C12=NC(C3=CCOCC3)=NN1C(=O)C(N1CCN(C(C3C(O)=C(C)N=CN=3)=O)CC1)=C(CC)N2CC(NC1=CC=C(C(F)(F)F)C=C1Cl)=O |
| Hazard Information | Back Directory | [Uses]
HRO761 (Werner syndrome RecQ helicase-IN-1) (example 42) is a potent Werner syndrome RecQ DNA helicase enzyme (WRN) inhibitor and can be used in cancer research[1]. | [References]
[1] Triazolo-pyrimidine analogues for treating diseases connected to the inhibiton of werner syndrome recq helicase (wrn). WO2022249060 |
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