| Identification | Back Directory | [Name]
2-Pyrrolidinecarboxamide, 1-acetyl-N-[4-[(aminoiminomethyl)amino]-1-(2-benzothiazolylcarbonyl)butyl]-4-hydroxy-, (2S,4R)- | [CAS]
287183-00-0 | [Synonyms]
2-Pyrrolidinecarboxamide, 1-acetyl-N-[4-[(aminoiminomethyl)amino]-1-(2-benzothiazolylcarbonyl)butyl]-4-hydroxy-, (2S,4R)- | [Molecular Formula]
C20H26N6O4S | [MOL File]
287183-00-0.mol | [Molecular Weight]
446.52 |
| Hazard Information | Back Directory | [Uses]
RWJ-58643 is a β-trypsin inhibitor that suppresses allergic inflammation. RWJ-58643 (100 mg) significantly reduced nasal allergy symptoms, eosinophil infiltration, and IL-5 levels at low doses. RWJ-58643 resulted in late eosinophilia and elevated IL-5 levels at high doses (300 mg and 600 mg). RWJ-58643 modulates allergic responses by inhibiting the release of β-trypsin from mast cells[1]. | [References]
[1] Effects of a reversible b-tryptase and trypsin inhibitor (RWJ-58643) on nasal allergic responses |
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