| Identification | Back Directory | [Name]
Methanone, [4-(2-furanyl)-1-(2-pyrimidinyl)-1H-pyrrol-3-yl](3,4,5-trimethoxyphenyl)- | [CAS]
2873383-67-4 | [Synonyms]
Tubulin inhibitor 30
Methanone, [4-(2-furanyl)-1-(2-pyrimidinyl)-1H-pyrrol-3-yl](3,4,5-trimethoxyphenyl)- | [Molecular Formula]
C22H19N3O5 | [MOL File]
2873383-67-4.mol | [Molecular Weight]
405.4 |
| Chemical Properties | Back Directory | [Boiling point ]
669.3±65.0 °C(Predicted) | [density ]
1.29±0.1 g/cm3(Predicted) | [form ]
Solid | [pka]
-2.46±0.33(Predicted) | [color ]
White to off-white |
| Hazard Information | Back Directory | [Uses]
Tubulin inhibitor 30 (Compound 15) is a tubulin assembly inhibitor with an IC50 of 0.52 μM. Tubulin inhibitor 30 can induce ferroptosis[1]. | [in vivo]
Tubulin inhibitor 30 (Compound 15) (25mg/kg; i.p.; every 2 days) inhibits the in vivo tumorigenicity of the human GBM cell line U-87 MG and the human OC cell line SKOV-3, and causes oxidative stress injury and Fe2+ accumulation in mice[1]. | Animal Model: | BALB/Cnu/nu mice, U-87 MG or SKOV-3 model[1] | | Dosage: | 25 mg/kg | | Administration: | Intraperitoneal injection, every 2 days | | Result: | Inhibited tumorigenicity and tumor volume. Caused oxidative stress injury and Fe2+ accumulation. |
| [References]
[1] Puxeddu M, et al. Induction of Ferroptosis in Glioblastoma and Ovarian Cancers by a New Pyrrole Tubulin Assembly Inhibitor. J Med Chem. 2022 Nov 17. DOI:10.1021/acs.jmedchem.2c01457 |
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