| Identification | Back Directory | [Name]
2-Amino-4-(3,4-difluorophenyl)-7-methoxy-4H-1-benzopyran-3-carbonitrile | [CAS]
2873399-22-3 | [Synonyms]
2-Amino-4-(3,4-difluorophenyl)-7-methoxy-4H-1-benzopyran-3-carbonitrile | [Molecular Formula]
C17H12F2N2O2 | [MOL File]
2873399-22-3.mol | [Molecular Weight]
314.29 |
| Hazard Information | Back Directory | [Uses]
Tubulin polymerization-IN-2 is a potent anticancer agent targeting to β-tubulin with an IC50 value of 0.92 μM. Tubulin polymerization-IN-2 shows promising activity against various leukemia, non-small lung, renal, prostate, and breast cancer cell lines[1]. | [References]
[1] Elshemy HAH, et al. Development of potential anticancer agents and apoptotic inducers based on 4-aryl-4H chromene scaffold: Design, synthesis, biological evaluation and insight on their proliferation inhibition mechanism. Bioorg Chem. 2022 Jan;118:105475. DOI:10.1016/j.bioorg.2021.105475 |
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