| Identification | Back Directory | [Name]
Benzamide, 2-(pentyloxy)-N-tricyclo[3.3.1.13,7]dec-1-yl- | [CAS]
2876918-67-9 | [Synonyms]
CB2R/FAAH modulator-3
N-(Adamantan-1-yl)-2-(pentyloxy)benzamide
Benzamide, 2-(pentyloxy)-N-tricyclo[3.3.1.13,7]dec-1-yl- | [Molecular Formula]
C22H31NO2 | [MOL File]
2876918-67-9.mol | [Molecular Weight]
341.49 |
| Chemical Properties | Back Directory | [Boiling point ]
495.0±28.0 °C(Predicted) | [density ]
1.10±0.1 g/cm3(Predicted) | [form ]
Solid | [pka]
14.68±0.20(Predicted) | [color ]
White to off-white |
| Hazard Information | Back Directory | [Uses]
CB2R/FAAH modulator-3 (compound 27) is a dual targeting modulator that acts as a CB2R agonist and FAAH inhibitor. The Ki values for CB2R/FAAH modulator-3 are 20.1 and 67.6 nM for CB2R and CB1R, respectively, and the IC50 value for FAAH is 3.4 μM. CB2R/FAAH modulator-3 can be used in studies related to cancer, deleterious inflammatory cascades occurring in neurodegenerative diseases, and COVID-19 infection[1]. | [IC 50]
CB1: 67.6 nM (Ki); CB2: 20.1 nM (Ki) | [References]
[1] Francesca Intranuovo, et al. Development of?N-(1-Adamantyl)benzamides as Novel Anti-Inflammatory Multitarget Agents Acting as Dual Modulators of the Cannabinoid CB2 Receptor and Fatty Acid Amide Hydrolase. J Med Chem. 2023 Jan 12;66(1):235-250. DOI:10.1021/acs.jmedchem.2c01084 |
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