| Identification | Back Directory | [Name]
CB2R/FAAH modulator-2 | [CAS]
2876918-68-0 | [Synonyms]
CB2R/FAAH modulator-2
N-(Adamantan-1-yl)-2-(cyclohexylmethoxy)benzamide | [Molecular Formula]
C24H33NO2 | [MOL File]
2876918-68-0.mol | [Molecular Weight]
367.53 |
| Chemical Properties | Back Directory | [Boiling point ]
532.8±33.0 °C(predicted) | [density ]
1.14±0.1 g/cm3(Temp: 20 °C; Press: 760 Torr)(predicted) | [form ]
Solid | [pka]
14.68±0.20(predicted) | [color ]
Light yellow to yellow |
| Hazard Information | Back Directory | [Uses]
CB2R/FAAH modulator-2 (compound 26) is a dual targeting modulator that acts as a CB2R agonist and FAAH inhibitor. The Ki values for CB2R/FAAH modulator-2 are 10.8 and 152.9 nM for CB2R and CB1R, respectively, and the IC50 value for FAAH is 6.2 μM. CB2R/FAAH modulator-2 can be used in studies related to cancer, deleterious inflammatory cascades occurring in neurodegenerative diseases, and COVID-19 infection[1]. | [IC 50]
CB1: 152.9 nM (Ki); CB2: 10.8 nM (Ki) | [References]
[1] Francesca Intranuovo, et al. Development of?N-(1-Adamantyl)benzamides as Novel Anti-Inflammatory Multitarget Agents Acting as Dual Modulators of the Cannabinoid CB2 Receptor and Fatty Acid Amide Hydrolase. J Med Chem. 2023 Jan 12;66(1):235-250. DOI:10.1021/acs.jmedchem.2c01084 |
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