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2877017-16-6

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2877017-16-6 Structure

2877017-16-6 Structure

Identification	Back Directory
[Name] PDE1-IN-6
[CAS] 2877017-16-6
[Synonyms] PDE1-IN-6
[Molecular Formula] C24H26F2N6O
[MOL File] 2877017-16-6.mol
[Molecular Weight] 452.5

Chemical Properties	Back Directory
[Boiling point ] 627.3±65.0 °C(predicted)
[density ] 1.28±0.1 g/cm3(Temp: 20 °C; Press: 760 Torr)(predicted)
[pka] 4.63±0.50(predicted)

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[Uses] PDE1-IN-6 (compound 6c) is a selectivity PDE1 inhibitor with the IC50 of 7.5 nM. PDE1-IN-6 significantly inhibits the proliferation and induced cell apoptosis in Acute myelogenous leukemia cells[1].
[References] [1] Le ML, et al. Discovery of novel selective phosphodiesterase?1 inhibitors for the treatment of acute myelogenous leukemia. Bioorg Chem. 2024;144:107114. DOI:10.1016/j.bioorg.2024.107114

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Company Name:	TargetMol Chemicals Inc.
Tel:	15002134094
Website:	https://www.targetmol.cn/

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