| Identification | Back Directory | [Name]
1H-Pyrazole-4-sulfonylchloride,1-methyl-(9CI) | [CAS]
288148-34-5 | [Synonyms]
EOS-61290
1-methyl-(9CI)
1-methyl-4-pyrazolesulfonyl chloride
1-methylpyrazole-4-sulfonyl chloride
4-(Chlorosulphonyl)-1-methyl-1H-pyrazole
1-Methyl-1H-pyrazole-4-sulphonyl chloride
1H-pyrazole-4-sulfonyl chloride, 1-methyl-
1-Methyl-1H-pyrazole-4-sulfonylchloride,97%
1H-Pyrazole-4-sulfonylchloride,1-methyl-(9CI)
1-methyl-1H-pyrazole-4-sulfonyl chloride(SALTDATA: FREE)
1H-Pyrazole-4-sulfonylchloride,1-methyl-(9CI) ISO 9001：2015 REACH | [Molecular Formula]
C4H5ClN2O2S | [MDL Number]
MFCD04968667 | [MOL File]
288148-34-5.mol | [Molecular Weight]
180.613 |
| Chemical Properties | Back Directory | [Boiling point ]
295.7±13.0 °C(Predicted) | [density ]
1.60±0.1 g/cm3(Predicted) | [storage temp. ]
Keep in dark place,Sealed in dry,Room Temperature | [form ]
crystalline solid | [pka]
-3.33±0.10(Predicted) | [color ]
White | [Sensitive ]
Moisture Sensitive | [InChI]
InChI=1S/C4H5ClN2O2S/c1-7-3-4(2-6-7)10(5,8)9/h2-3H,1H3 | [InChIKey]
RDAVKKQKMLINOH-UHFFFAOYSA-N | [SMILES]
N1(C)C=C(S(Cl)(=O)=O)C=N1 |
| Safety Data | Back Directory | [Hazard Codes ]
Xi | [Risk Statements ]
43 | [Safety Statements ]
36/37 | [RIDADR ]
UN3265 | [WGK Germany ]
3 | [HazardClass ]
8 | [HazardClass ]
IRRITANT | [HS Code ]
2933199090 |
| Hazard Information | Back Directory | [Uses]
1-Methyl-1H-pyrazole-4-sulfonyl Chloride is used as a reagent in the preparation of benzoindazoles as glucocorticoid receptor modulators. | [Synthesis]
1-Methyl-1H-pyrazole (100 g, 1.18 mol) was slowly added dropwise to chlorosulfonic acid (325 mL, 4.84 mol) at 0 °C and under nitrogen protection, keeping stirring. The reaction mixture was then heated to reflux at 110 °C for 3 hours. Upon completion of the reaction, the mixture was cooled to room temperature and quenched by careful pouring into crushed ice with continuous stirring. The precipitated white solid product was collected by vacuum filtration and washed well with cold water. Finally, the product was dried under vacuum to afford 1-methyl-1H-pyrazole-4-sulfonyl chloride (72.2 g, 33% yield), which can be used in subsequent reactions without further purification. | [References]
[1] Patent: WO2009/29439, 2009, A1. Location in patent: Page/Page column 24
[2] Patent: US6103708, 2000, A
[3] Patent: WO2005/97162, 2005, A2. Location in patent: Page/Page column 432 |
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