| Identification | Back Directory | [Name]
1H-Pyrano[3',4':6,7]indolizino[1,2-b]quinoline-3,14(4H,12H)-dione, 9-(3-aminopropoxy)-4,11-diethyl-4-hydroxy-, (4S)- | [CAS]
288247-87-0 | [Synonyms]
T-2513
1H-Pyrano[3',4':6,7]indolizino[1,2-b]quinoline-3,14(4H,12H)-dione, 9-(3-aminopropoxy)-4,11-diethyl-4-hydroxy-, (4S)- | [Molecular Formula]
C25H27N3O5 | [MDL Number]
MFCD34469541 | [MOL File]
288247-87-0.mol | [Molecular Weight]
449.5 |
| Hazard Information | Back Directory | [Uses]
T-2513 is a selective topoisomerase I inhibitor. T-2513 binds covalently to and stabilizes the topoisomerase I-DNA complex and inhibits DNA replication and RNA synthesis, ultimately leading to cell death[1]. | [in vivo]
T-2513 (1-100 mg/kg) shows Antitumor Activity against Walker-256 carcinoma[2]. | Animal Model: | Rats bearing Walker-256 carcinoma[2] | | Dosage: | 1, 10, and 100 mg/kg | | Administration: | | | Result: | The ED50 was 23 mg/kg. |
| [IC 50]
Topoisomerase I | [References]
[1] Stephan A Veltkamp, et al. Clinical and pharmacologic study of the novel prodrug delimotecan (MEN 4901/T-0128) in patients with solid tumors. Clin Cancer Res. 2008 Nov 15;14(22):7535-44. DOI:10.1158/1078-0432.CCR-08-0438
[2] S Okuno, et al. Complete regression of xenografted human carcinomas by camptothecin analogue-carboxymethyl dextran conjugate (T-0128). Cancer Res. 2000 Jun 1;60(11):2988-95. PMID:10850447 |
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