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2883007-69-8

2883007-69-8 Structure

2883007-69-8 Structure
IdentificationBack Directory
[Name]

TAS2R14 agonist-2
[CAS]

2883007-69-8
[Synonyms]

TAS2R14 agonist-2
[Molecular Formula]

C13H10F3N7
[MOL File]

2883007-69-8.mol
[Molecular Weight]

321.26
Chemical PropertiesBack Directory
[Boiling point ]

512.6±60.0 °C(predicted)
[density ]

1.494±0.06 g/cm3(Temp: 20 °C; Press: 760 Torr)(predicted)
[form ]

Solid
[pka]

3.95±0.10(predicted)
[color ]

White to off-white
Hazard InformationBack Directory
[Uses]

TAS2R14 agonist-2 (compound 28.1) is a potent and selective TAS2R14 inhibitor with an EC50 value of 72 nM[1].
[References]

[1] Waterloo L, et al. Discovery of 2-Aminopyrimidines as Potent Agonists for the Bitter Taste Receptor TAS2R14. J Med Chem. 2023 Mar 9;66(5):3499-3521. DOI:10.1021/acs.jmedchem.2c01997
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