| Chemical Properties | Back Directory | [Boiling point ]
463.321±40.00 °C(Press: 760.00 Torr)(predicted) | [density ]
1.299±0.06 g/cm3(Temp: 25 °C; Press: 760 Torr)(predicted) | [pka]
6.680±0.30(predicted) |
| Hazard Information | Back Directory | [Uses]
BTK-IN-16 is a dual inhibitor of BTK wild type and C481S mutant of Bruton’s tyrosine kinase (BTK) with IC50s of 5.1 and 4.1 μM. BTK-IN-16 can be used for the research of autoimmune diseases and chronic lymphocytic leukemia[1]. | [References]
[1] Kim T, et al. Two-Track Virtual Screening Approach to Identify the Dual Inhibitors of Wild Type and C481S Mutant of Bruton's Tyrosine Kinase. J Chem Inf Model. 2022 Aug 24. DOI:10.1021/acs.jcim.2c00623 |
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