| Identification | Back Directory | [Name]
1-Cyclopropyl-6-fluoro-1,4-dihydro-4-oxo-7-[4-[2-oxo-2-[[4-[(2-quinoxalinylamino)sulfonyl]phenyl]amino]ethyl]-1-piperazinyl]-3-quinolinecarboxylic acid | [CAS]
2883403-36-7 | [Synonyms]
Topoisomerase IV inhibitor 2
1-Cyclopropyl-6-fluoro-1,4-dihydro-4-oxo-7-[4-[2-oxo-2-[[4-[(2-quinoxalinylamino)sulfonyl]phenyl]amino]ethyl]-1-piperazinyl]-3-quinolinecarboxylic acid | [Molecular Formula]
C33H30FN7O6S | [MOL File]
2883403-36-7.mol | [Molecular Weight]
671.7 |
| Hazard Information | Back Directory | [Uses]
Topoisomerase IV inhibitor 2 (compound 5d) is a potent DNA topoisomerase IV (TOPO IV) inhibitor with IC50s of 0.35 μM and 0.55 μM for TOPO IV and DNA gyrase, respectively. Topoisomerase IV inhibitor 2 has anti-bacterial activity, with MICs of 1.985 μM and 0.744 μM in Staphylococcus aureus Newman and Escherichia coli ATCC8739, respectively[1]. | [IC 50]
TOPO IV: 0.35 μM (IC50) | [References]
[1] Ibrahim NM, et al. Design and synthesis of ciprofloxacin-sulfonamide hybrids to manipulate ciprofloxacin pharmacological qualities: Potency and side effects. Eur J Med Chem. 2022;228:114021. DOI:10.1016/j.ejmech.2021.114021 |
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