| Identification | Back Directory | [Name]
1-OXAZOLO[4,5-B]PYRIDIN-2-YL-OCTADECA-9-YN-1-ONE | [CAS]
288862-89-5 | [Synonyms]
CAY10401
1-oxazolo[4,5-b]pyridin-2-yl-9-octadecyn-1-one
1-OXAZOLO[4,5-B]PYRIDIN-2-YL-OCTADECA-9-YN-1-ONE
9-Octadecyn-1-one, 1-oxazolo[4,5-b]pyridin-2-yl-
1-([1,3]oxazolo[4,5-b]pyridin-2-yl)octadec-9-yn-1-one | [Molecular Formula]
C24H34N2O2 | [MDL Number]
MFCD03456371 | [MOL File]
288862-89-5.mol | [Molecular Weight]
382.54 |
| Chemical Properties | Back Directory | [Boiling point ]
508.3±56.0 °C(Predicted) | [density ]
1.029±0.06 g/cm3(Predicted) | [solubility ]
DMF: 20 mg/ml; DMSO: 20 mg/ml; DMSO:PBS (pH 7.2)(1:1): .15 mg/ml; Ethanol: 20 mg/ml | [pka]
-1.77±0.50(Predicted) |
| Hazard Information | Back Directory | [Description]
Fatty acid amide hydrolase (FAAH) is the enzyme responsible for hydrolysis and inactivation of fatty acid amides including anandamide and oleamide. CAY10401 is a selective, potent inhibitor of rat FAAH exhibiting a Ki value of 0.14 nM. CAY10401 is approximately 580 fold more potent than oleyl trifluoromethyl ketone when assayed under the same conditions. | [Uses]
FAAH-IN-9 (compoud 59) is an irreversible oleoyl inhibitor of FAAH with Ki of 0.02 nM. | [Definition]
ChEBI: CAY10401 is an oxazolopyridine. | [References]
[1] Exceptionally potent inhibitors of fatty acid amide hydrolase: The enzyme responsible for degradation of endogenous oleamide and anandamide |
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