| Chemical Properties | Back Directory | [Boiling point ]
565.197±60.00 °C(Press: 760.00 Torr)(predicted) | [density ]
1.304±0.06 g/cm3(Temp: 25 °C; Press: 760 Torr)(predicted) | [solubility ]
DMF: 30 mg/ml
DMSO: 30 mg/ml
Ethanol: 10 mg/mlPBS (pH 7.2): Slightly soluble | [pka]
8.074±0.42(predicted) |
| Hazard Information | Back Directory | [Uses]
JAK-IN-30 (compound 31) is a water-soluble JAK inhibitor with IC50 values of 2, 15, 18 and 2 nM for JAK2, JAK1, JAK3 and TYK2, respectively. JAK-IN-30 has research potential for dry eye disease (DED)[1]. | [IC 50]
JAK1: 15 nM (IC50); JAK2: 2 nM (IC50); JAK3: 18 nM (IC50); Tyk2: 2 nM (IC50) | [References]
[1] Gordhan HM, et al. Eyes on Topical Ocular Disposition: The Considered Design of a Lead Janus Kinase (JAK) Inhibitor That Utilizes a Unique Azetidin-3-Amino Bridging Scaffold to Attenuate Off-Target Kinase Activity, While Driving Potency and Aqueous Solubility. J Med Chem. 2023 Jul 13;66(13):8929-8950. DOI:10.1021/acs.jmedchem.3c00519 |
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