| Identification | Back Directory | [Name]
INDEX NAME NOT YET ASSIGNED | [CAS]
2891574-93-7 | [Synonyms]
Sulfate(1-), [3-carboxylato-4-[[2-(6-cyano-1H-indol-3-yl)ethyl]amino]phenyl]pentafluoro-, hydrogen (1:1), (OC-6-21)- | [Molecular Formula]
C18H13F5N3O2S.H | [MOL File]
2891574-93-7.mol | [Molecular Weight]
431.38 |
| Hazard Information | Back Directory | [Uses]
EF-4-177 is an orally active and allosteric CDK2 inhibitor with the IC50 of 87 nM. EF-4-177 can disrupt spermatogenesis[1][2]. | [IC 50]
CDK2/cyclinE: 87 nM (IC50) | [References]
[1] Faber EB, et al. Screening through Lead Optimization of High Affinity, Allosteric Cyclin-Dependent Kinase 2 (CDK2) Inhibitors as Male Contraceptives That Reduce Sperm Counts in Mice. J Med Chem. 2023;66(3):1928-1940. DOI:10.1021/acs.jmedchem.2c01731
[2] Huang Y, et al. Targeting cyclin-dependent kinases: From pocket specificity to drug selectivity. Eur J Med Chem. Published online May 29, 2024. DOI:10.1016/j.ejmech.2024.116547 |
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