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2892065-45-9

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2892065-45-9 Structure

2892065-45-9 Structure
IdentificationBack Directory
[Name]

2,6-Piperidinedione, 3-[1,3-dihydro-1-oxo-5-[[(1S,2S)-2-(3-phenyl-1-azetidinyl)cyclohexyl]oxy]-2H-isoindol-2-yl]-, (3S)-
[CAS]

2892065-45-9
[Synonyms]

PLX-4545
(S)-3-(1-oxo-5-(((1S,2S)-2-(3-phenylazetidin-1-yl)cyclohexyl)oxy)isoindolin-2-yl)piperidine-2,6-dione
2,6-Piperidinedione, 3-[1,3-dihydro-1-oxo-5-[[(1S,2S)-2-(3-phenyl-1-azetidinyl)cyclohexyl]oxy]-2H-isoindol-2-yl]-, (3S)-
[Molecular Formula]

C28H31N3O4
[MOL File]

2892065-45-9.mol
[Molecular Weight]

473.56
Chemical PropertiesBack Directory
[Boiling point ]

726.7±60.0 °C(Predicted)
[density ]

1.309±0.06 g/cm3(Predicted)
[pka]

10.78±0.40(Predicted)
Hazard InformationBack Directory
[Uses]

PLX-4545 is an orally available, cereblon-based molecular glue degrader of IKZF2 (zinc finger transcription factor Helios), which can reprogram immunosuppressive regulatory T cells into pro-inflammatory effector T cells, thereby enhancing anti-tumor immune responses[1].
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