| Identification | Back Directory | [Name]
[1,1′-Biphenyl]-3-sulfonyl fluoride, 3′,5′-difluoro-4′-[(2S)-2-[(2H-tetrazol-5-ylamino)carbonyl]hexyl]- | [CAS]
2894832-05-2 | [Synonyms]
WM-586
[1,1′-Biphenyl]-3-sulfonyl fluoride, 3′,5′-difluoro-4′-[(2S)-2-[(2H-tetrazol-5-ylamino)carbonyl]hexyl]- | [Molecular Formula]
C20H20F3N5O3S | [MOL File]
2894832-05-2.mol | [Molecular Weight]
467.47 |
| Hazard Information | Back Directory | [Uses]
WM-586 is a covalent WDR5 inhibitor that disrupts the binding of WDR5 to MYC. WM-586 specifically decreases cellular WDR5 and MYC interaction with the IC50 of 101 nM in HTRF assay[1]. | [References]
[1] Ding J, et al. Discovery of Potent Small-Molecule Inhibitors of WDR5-MYC Interaction. ACS Chem Biol. 2023 Jan 20;18(1):34-40. DOI:10.1021/acschembio.2c00843 |
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