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29023-48-1

29023-48-1 Structure

29023-48-1 Structure
IdentificationBack Directory
[Name]

1-(tert-butylamino)-3-[[4-(morpholin-4-yl)-1,2,5-thiadiazol-3-yl]oxy]propan-2-ol
[CAS]

29023-48-1
[Synonyms]

Racemic timolol
rac Timolol-d5 Maleate
(+/-)-Timolol-d5 Maleate
1,2,5-Thiadiazole, 2-propanol deriv.
1-[(1,1-DiMethylethyl)aMino]-3-[[4-(4-Morpholinyl)-1,2,5-thiadiazol-3-yl]oxy]-
3-Morpholino-4-(3-tert-butylamino-2-hydroxypropoxy)-1,2,5-thiadiazole-d5 Maleate
2-Propanol, 1-(tert-butylamino)-3-[(4-morpholino-1,2,5-thiadiazol-3-yl)oxy]- (8CI)
1-[(1,1-Dimethylethyl)amino]-3-[[4-(4-morpholinyl)-1,2,5-thiadiazol-3-yl]oxy]-2-propanol
2-Propanol, 1-[(1,1-dimethylethyl)amino]-3-[[4-(4-morpholinyl)-1,2,5-thiadiazol-3-yl]oxy]- (9CI)
1-[(1,1-Dimethylethyl)amino]-3-[[4-(4-morpholinyl)-1,2,5-thiadiazol-3-yl]oxy]-2-propanol-d5 Maleate
[EINECS(EC#)]

249-374-9
[Molecular Formula]

C13H24N4O3S
[MDL Number]

MFCD28899668
[MOL File]

29023-48-1.mol
[Molecular Weight]

316.42
Chemical PropertiesBack Directory
[Appearance]

White Solid
[Melting point ]

210-212°C
[Boiling point ]

487.2±45.0 °C(Predicted)
[density ]

1.224±0.06 g/cm3(Predicted)
[storage temp. ]

-20°C Freezer
[solubility ]

DMSO (Slightly), Methanol (Slightly)
[form ]

Solid
[pka]

13.38±0.20(Predicted)
[color ]

White
Hazard InformationBack Directory
[Chemical Properties]

White Solid
[Uses]

Antihypertensive; antiarrhythmic (class II); antianginal; antiglaucoma agent
[Definition]

ChEBI: Timolol is 1,2,5-Thiadiazole substituted at the 3 position by a 3-(tert-butylamino)-2-hydroxypropoxy group and at the 4 position by a morpholin-4-yl group. The (S)-(-) enantiomer, also known as timolol, is a beta-adrenergic antagonist and is used in the mangement of glaucoma, hypertension, angina pectoris and myocardial infarction, and for the prevention of migraine. It is a member of thiadiazoles and a member of morpholines. It derives from a hydride of a 1,2,5-thiadiazole.
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