| Identification | Back Directory | [Name]
4-Methanesulfonyl-piperidine | [CAS]
290328-55-1 | [Synonyms]
EOS-61037
4-Methanesulfonyl-piperidine
4-(Methylsulfonyl)piperid...
Piperidine, 4-(Methylsulfonyl)-
4-Methanesulfonylpiperidine hydrochloride
4-(methylsulfonyl)piperidine hydrochloride | [EINECS(EC#)]
1533716-785-6 | [Molecular Formula]
C6H13NO2S | [MDL Number]
MFCD11043260 | [MOL File]
290328-55-1.mol | [Molecular Weight]
163.24 |
| Chemical Properties | Back Directory | [Boiling point ]
336.9±31.0 °C(Predicted) | [density ]
1.18±0.1 g/cm3(Predicted) | [storage temp. ]
Keep in dark place,Sealed in dry,2-8°C | [pka]
9.22±0.10(Predicted) | [Appearance]
White to off-white Solid |
| Hazard Information | Back Directory | [Synthesis]
General procedure for the synthesis of 4-methylsulfonylpiperidine from tert-butyl 4-(methylsulfonyl)piperidine-1-carboxylate (Step 4): tert-butyl 4-(methylsulfonyl)piperidine-1-carboxylate obtained in Step 3 of Reference Example 12 was dissolved in ethyl acetate (16 mL), followed by the addition of a 4.0 mol/L dioxane solution of hydrogen chloride (12 mL). The reaction mixture was stirred at room temperature for 3 hours. Upon completion of the reaction, the precipitated solid was collected by filtration to afford the target product 4-(methylsulfonyl)piperidine (1.4 g, 76% yield). The structure of the product was confirmed by 1H-NMR (DMSO-d6, 270 MHz) with the following chemical shifts δ (ppm): 3.41-3.31 (m, 3H), 2.97 (s, 3H), 2.97-2.82 (m, 2H), 2.18-2.13 (m, 2H), 1.92-1.73 (m, 2H). | [References]
[1] Patent: EP1642880, 2006, A1. Location in patent: Page/Page column 112
[2] Patent: US2003/100567, 2003, A1 |
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| Company Name: |
Tetranov Biopharm
|
| Tel: |
13526569071 |
| Website: |
http://www.leadmedpharm.com/index.html |
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