| Hazard Information | Back Directory | [Uses]
TRK II-IN-1 is a potent type II TRK inhibitor, with IC50s of 3.3, 6.4, 4.3 and 9.4 nM, for TRKA/B/C and TRKAG667C, respectively. TRK II-IN-1 also inhibits FLT3, RET, and VEGFR2 with IC50s of 1.3, 9.9, and 71.1 nM, respectively. TRK II-IN-1 can be used for the research of TRK driven cancers[1]. | [IC 50]
TrkA: 3.3 nM (IC50); TrkB: 6.4 nM (IC50); TrkC: 4.3 nM (IC50); TRKAG667C: 9.4 nM (IC50); FLT3: 1.3 nM (IC50); RET: 9.9 nM (IC50); VEGFR2: 71.1 nM (IC50) | [References]
[1] Xiang S, et, al. Switch type I to type II TRK inhibitors for combating clinical resistance induced by xDFG mutation for cancer therapy. Eur J Med Chem. 2023 Jan 5;245(Pt 1):114899. DOI:10.1016/j.ejmech.2022.114899 |
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