| Identification | Back Directory | [Name]
SILA-123 | [CAS]
2911585-37-8 | [Synonyms]
SILA-123
Urea, N-[4-(3-amino-6-methylisoxazolo[5,4-b]pyridin-4-yl)phenyl]-N′-[4-(1,1-dimethylethyl)phenyl]- | [Molecular Formula]
C24H25N5O2 | [MOL File]
2911585-37-8.mol | [Molecular Weight]
415.49 |
| Chemical Properties | Back Directory | [Boiling point ]
543.9±50.0 °C(predicted) | [density ]
1.283±0.06 g/cm3(Temp: 20 °C; Press: 760 Torr)(predicted) | [pka]
13.95±0.70(predicted) |
| Hazard Information | Back Directory | [Uses]
SILA-123 is a FLT3 inhibitor (FLT3-WT: IC50=2.1 nM; FLT3-ITD: IC50=1.0 nM). SILA-123 inhibits FLT3 phosphorylation and downstream signaling pathways, leading to apoptosis by arresting cell cycle progression at the G0/G1 phase. SILA-123 can be used in the study of acute myeloid leukemia[1]. | [References]
[1] Wei T H, et al. Discovery of SILA-123 as a Highly Potent FLT3 Inhibitor for the Treatment of Acute Myeloid Leukemia with Various FLT3 Mutations[J]. Journal of Medicinal Chemistry, 2024. DOI:10.1021/acs.jmedchem.4c00529 |
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