| Identification | Back Directory | [Name]
2-Amino-5-bromobenzaldehyde | [CAS]
29124-57-0 | [Synonyms]
Ambroxol Imp.18
Ambroxol Impurity 54
Bromhexine Impurity 10
4-Bromo-2-formylaniline
5-Bromoanthranilaldehyde
2-Amino-5-brombenzaldehyd
2-Amino-5-bromobenzaldehyde
Benzaldehyde,2-aMino-5-broMo-
aminobromobenzenecarbaldehyde
2-Amino-5-bromobenzaldehyde,97%
(4R)-4-methyl-1,3-oxazolidin-2-one
2-Amino-5-bromobenzenecarbaldehyde
5-Bromoanthranilaldehyde, 4-Bromo-2-formylaniline | [Molecular Formula]
C7H6BrNO | [MDL Number]
MFCD10696879 | [MOL File]
29124-57-0.mol | [Molecular Weight]
200.04 |
| Chemical Properties | Back Directory | [Melting point ]
75-77° | [Boiling point ]
290.3±25.0 °C(Predicted) | [density ]
1.673 | [storage temp. ]
Keep in dark place,Inert atmosphere,Store in freezer, under -20°C | [form ]
Solid | [pka]
-0.35±0.10(Predicted) | [color ]
Yellow | [Sensitive ]
Air Sensitive | [CAS DataBase Reference]
29124-57-0 |
| Hazard Information | Back Directory | [Uses]
Participate in synthesis and structure activity of novel camptothecin analogs. | [Synthesis]
General procedure for the synthesis of 2-amino-5-bromobenzaldehyde from 2-amino-5-bromobenzenemethanol: With reference to Example 286, 2-amino-5-bromobenzenemethanol (23.32 g) and activated manganese dioxide (58.5 g) were added to acetone (300 ml). The reaction mixture was stirred at room temperature for 17.5 hours and then filtered. The filtrate was concentrated under reduced pressure to give 2-amino-5-bromobenzaldehyde (16.41 g, 71% yield). The structure of the product was confirmed by 1H NMR (200 MHz, CDCl3): δ 6.10-6.20 (2H, br), 6.57 (1H, d, J=8.8 Hz), 7.38 (1H, dd, J=8.8,2.4 Hz), 7.59 (1H, d, J=2.4 Hz), 9.81 (1H, s). | [References]
[1] Organic Syntheses, 2013, vol. 90, p. 240 - 250
[2] ChemistryOpen, 2015, vol. 4, # 2, p. 107 - 110
[3] Patent: CN107304201, 2017, A. Location in patent: Paragraph 0061; 0065
[4] Patent: US6166006, 2000, A
[5] Journal of Organic Chemistry, 2010, vol. 75, # 4, p. 1188 - 1196 |
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