| Identification | Back Directory | [Name]
METHYL (TRIMETHYLSILYL)ACETATE | [CAS]
2916-76-9 | [Synonyms]
METHYLTRIMETHYLSILICATE
METHYL (TRIMETHYLSILYL)ACETATE
Methyl 2-(triMethylsilyl)acetate
Methyl (trimethylsilyl)acetate,98%
Trimethylsilylacetic acid methyl ester
2-(Trimethylsilyl)acetic acid methyl ester
2-[Dimethyl(methyl)silyl]acetic acid methyl ester | [EINECS(EC#)]
220-845-0 | [Molecular Formula]
C6H14O2Si | [MDL Number]
MFCD00008450 | [MOL File]
2916-76-9.mol | [Molecular Weight]
146.26 |
| Chemical Properties | Back Directory | [Appearance]
CLEAR COLOURLESS LIQUID | [Boiling point ]
38-39 °C13 mm Hg(lit.)
| [density ]
0.891 g/mL at 25 °C(lit.)
| [refractive index ]
n20/D 1.414(lit.)
| [Fp ]
91 °F
| [storage temp. ]
Flammables area | [form ]
liquid | [Specific Gravity]
0.890 | [Hydrolytic Sensitivity]
2: reacts with aqueous acid | [BRN ]
1098961 | [InChI]
InChI=1S/C6H14O2Si/c1-8-6(7)5-9(2,3)4/h5H2,1-4H3 | [InChIKey]
JIHUZDFFYVRXKP-UHFFFAOYSA-N | [SMILES]
C(OC)(=O)C[Si](C)(C)C |
| Hazard Information | Back Directory | [Chemical Properties]
CLEAR COLOURLESS LIQUID | [Uses]
Methyl 2-(Trimethylsilyl)acetate is a useful compound in the organic synthesis. | [General Description]
Methyl trimethylsilylacetate on reaction with lithium diisopropylamide in THF at -78°C yields methyl lithiotrimethylsilylacetate. It also undergoes Peterson olefination to yield mainly Z-isomers of steroid 17β-side chain methyl acrylates. | [Purification Methods]
Methyl trimethylsilylacetate [2916-76-9] M 146.3, b 65-68o/50mm, d 4 0.89. Dissolve it in Et2O, shaken with 1M HCl, wash with H2O, aqueous saturated NaHCO3, H2O again, and dry it (a precipitate may be formed in the NaHCO3 solution and should be drawn off and discarded). The solvent is distilled off, and the residue is fractionated through a good column. IR (CHCl3) max 1728cm1 . [Fessenden & Fessenden J Org Chem 32 3535 1967, Matsuda et al. J Org Chem 45 237 1980, Beilstein 4 III 1855, 4 IV 3974 for Et ester.] |
| Safety Data | Back Directory | [Hazard Codes ]
F,Xi | [Risk Statements ]
11-36/37/38 | [Safety Statements ]
16-26-36 | [RIDADR ]
UN 3272 3/PG 3
| [WGK Germany ]
3
| [F ]
10-21 | [TSCA ]
No | [HazardClass ]
3.1 | [PackingGroup ]
II | [HS Code ]
29319090 | [Storage Class]
3 - Flammable liquids | [Hazard Classifications]
Eye Irrit. 2
Flam. Liq. 3
Skin Irrit. 2
STOT SE 3 |
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