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2916371-54-3

2916371-54-3 Structure

2916371-54-3 Structure
IdentificationBack Directory
[Name]

Cisd2 agonist 1
[CAS]

2916371-54-3
[Synonyms]

Cisd2 agonist 1
[Molecular Formula]

C14H13FN2O3S
[MOL File]

2916371-54-3.mol
[Molecular Weight]

308.33
Chemical PropertiesBack Directory
[Boiling point ]

412.069±45.00 °C(Press: 760.00 Torr)(predicted)
[density ]

1.411±0.06 g/cm3(Temp: 25 °C; Press: 760 Torr)(predicted)
[form ]

Solid
[pka]

11.037±0.70(predicted)
[color ]

Off-white to light yellow
Hazard InformationBack Directory
[Uses]

Cisd2 agonist 1 (Compound 4q) is a Cisd2 agonist (EC50: 34 nM). Cisd2 agonist 1 enhances the Cisd2 expression and improves the pathological changes in the fatty livers. Cisd2 agonist 1 has good metabolic stability. Cisd2 agonist 1 can be used for research of NAFLD[1].
[References]

[1] Yao CH, et al. Discovery of tetrasubstituted thiophenes as Cisd2 activators: A potential novel therapeutic option in nonalcoholic fatty liver disease. Eur J Med Chem. 2023 Oct 5;258:115583. DOI:10.1016/j.ejmech.2023.115583
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